Amyotrophic lateral sclerosis 8: ALS8. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner due to mutation in a gene on chromosome 20ptel.
Showing posts with label als. Show all posts
Showing posts with label als. Show all posts
Thursday, July 23, 2009
Wednesday, July 22, 2009
Definition of Amyotrophic lateral sclerosis 7
Amyotrophic lateral sclerosis 7: ALS7. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner due to mutation in a gene on chromosome 20ptel.
Definition of Amyotrophic lateral sclerosis 6
Amyotrophic lateral sclerosis 6: ALS6. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner due to mutation in a gene on chromosome 16q12.
Definition of Amyotrophic lateral sclerosis 5
Amyotrophic lateral sclerosis 5: ALS5. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal recessive manner due to mutation in a gene on chromosome 15q15.1-q21.1.
Definition of Amyotrophic lateral sclerosis 4
Amyotrophic lateral sclerosis 4: ALS4. A juvenile-onset form of amyotrophic lateral sclerosis (ALS) with no bulbar involvement, inherited in an autosomal dominant manner and caused by mutation in a gene on chromosome 9q34.
Definition of Amyotrophic lateral sclerosis 3
Amyotrophic lateral sclerosis 3: ALS3. An adult-onset form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner and caused by mutation in a gene on chromosome 18q21.
Definition of Amyotrophic lateral sclerosis 2
Amyotrophic lateral sclerosis 2: ALS2. A juvenile-onset form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal recessive manner and caused by mutation in the gene encoding alsin on chromosome 2q33.
Definition of Amyotrophic lateral sclerosis 1
Amyotrophic lateral sclerosis 1: ALS1. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner and caused by mutation in the superoxide dismutase-1 gene (SOD1) on chromosome 21q22.1. About 15 to 20% of familial ALS is type 1 (ALS1). Sporadic cases of ALS are sometimes due to new mutation in the SOD1 gene.
Amyotrophic lateral sclerosis (ALS): A classic motor neuron
disease. Motor neuron diseases are progressive chronic diseases of
the nerves that come from the spinal cord responsible for supplying
electrical stimulation to the muscles. This stimulation is
necessary for the movement of body parts.
LOU GEHRIG'S DISEASE: Amyotrophic lateral sclerosis is quite a mouthful. The
disease is therefore usually referred to simply as ALS. In North
America it is sometimes called "Lou Gehrig's disease" after the great
durable baseball player who had it. The movie, "Pride of the
Yankees", tells the his life story. As a New York Yankee, Gehrig was named the American League's most valuable player 4 times (in 1927, 1931, 1934 and 1936). In 14 seasons Gehrig did not miss a single game for a total of 2,130 games. Gehrig was born in 1903, and he died in 1941 at the age of 38.
EPIDEMIOLOGY: ALS strikes in mid-life, most often in the
fifth through seventh decades of life. Men are about one-and-a-half
times more
likely to have the disease as women. It affects about 20,000
Americans with 5,000 new cases occurring in the United States each
year.
THE DISEASE PROCESS: ALS occurs when specific nerve cells
in the brain and spinal
cord that control voluntary movement gradually degenerate. The loss
of these motor neurons causes the muscles under their control to
weaken and waste away, leading to paralysis. The cause of this
disease process is still unknown.
SIGNS AND SYMPTOMS: ALS manifests itself in different ways,
depending on which muscles weaken first. Symptoms may include
tripping and falling, loss of motor control in hands and arms,
difficulty speaking, swallowing and/or breathing, persistent fatigue,
and twitching and cramping, sometimes quite severely.
TREATMENT: There is no cure for ALS; nor is there a proven
therapy that will prevent or reverse the course of the disorder. The
Food and Drug Administration (FDA) approved riluzole, the first drug
that has been shown to prolong the survival of ALS patients. Patients
may also
receive supportive treatments that address some of their symptoms.
PROGNOSIS (OUTLOOK): ALS is progressive and fatal. The
usual causes of death of patients with motor neuron diseases are not
directly related to the disease, but result from simultaneous
additional illnesses which ultimately occur because of weakness of
the body. These illnesses are often infections.
DURATION OF DISEASE: ALS usually leads to death within 5
years of the time the diagnosis of ALS is made; the range is from 2
to 7 years.
disease. Motor neuron diseases are progressive chronic diseases of
the nerves that come from the spinal cord responsible for supplying
electrical stimulation to the muscles. This stimulation is
necessary for the movement of body parts.
LOU GEHRIG'S DISEASE: Amyotrophic lateral sclerosis is quite a mouthful. The
disease is therefore usually referred to simply as ALS. In North
America it is sometimes called "Lou Gehrig's disease" after the great
durable baseball player who had it. The movie, "Pride of the
Yankees", tells the his life story. As a New York Yankee, Gehrig was named the American League's most valuable player 4 times (in 1927, 1931, 1934 and 1936). In 14 seasons Gehrig did not miss a single game for a total of 2,130 games. Gehrig was born in 1903, and he died in 1941 at the age of 38.
EPIDEMIOLOGY: ALS strikes in mid-life, most often in the
fifth through seventh decades of life. Men are about one-and-a-half
times more
likely to have the disease as women. It affects about 20,000
Americans with 5,000 new cases occurring in the United States each
year.
THE DISEASE PROCESS: ALS occurs when specific nerve cells
in the brain and spinal
cord that control voluntary movement gradually degenerate. The loss
of these motor neurons causes the muscles under their control to
weaken and waste away, leading to paralysis. The cause of this
disease process is still unknown.
SIGNS AND SYMPTOMS: ALS manifests itself in different ways,
depending on which muscles weaken first. Symptoms may include
tripping and falling, loss of motor control in hands and arms,
difficulty speaking, swallowing and/or breathing, persistent fatigue,
and twitching and cramping, sometimes quite severely.
TREATMENT: There is no cure for ALS; nor is there a proven
therapy that will prevent or reverse the course of the disorder. The
Food and Drug Administration (FDA) approved riluzole, the first drug
that has been shown to prolong the survival of ALS patients. Patients
may also
receive supportive treatments that address some of their symptoms.
PROGNOSIS (OUTLOOK): ALS is progressive and fatal. The
usual causes of death of patients with motor neuron diseases are not
directly related to the disease, but result from simultaneous
additional illnesses which ultimately occur because of weakness of
the body. These illnesses are often infections.
DURATION OF DISEASE: ALS usually leads to death within 5
years of the time the diagnosis of ALS is made; the range is from 2
to 7 years.
Thursday, July 16, 2009
Definition of ALS
ALS: Amyotrophic lateral sclerosis. ALS has two meanings. One meaning of ALS refers to several adult diseases characterized by progressive degeneration of motor neurons. (In the UK, the term "motor neuron disease" is used for these disorders.) The second meaning of ALS refers to a specific form of motor neuron disease in which there are both upper and lower motor neuron signs. Motor neuron diseases such as ALS are progressive chronic diseases of the nerves that come from the spinal cord and supply electrical
stimulation to the muscles. This stimulation is necessary for the movement of body parts.
Amyotrophic lateral sclerosis is quite a mouthful. The disease is therefore usually referred to simply as ALS or in North America as Lou Gehrig's disease after the great baseball player who died of it.
ALS strikes in mid-life, most often in the fifth through seventh decades of life. Men are about one-and-a-half
times more likely to have the disease as women.
ALS occurs when specific nerve cells in the brain and spinal
cord that control voluntary movement gradually degenerate. The loss
of these motor neurons causes the muscles under their control to
weaken and waste away, leading to paralysis.
ALS manifests itself in different ways, depending on which muscles weaken first. Symptoms may include
tripping and falling, loss of motor control in hands and arms,
difficulty speaking, swallowing and/or breathing, persistent fatigue,
and twitching and cramping, sometimes quite severely.
There is no cure for ALS; nor is there a proven therapy that will prevent or reverse the course of the disorder. The
Food and Drug Administration (FDA) approved riluzole, the first drug
that has been shown to prolong the survival of ALS patients. Patients
may also receive supportive treatments that address some symptoms.
ALS is progressive and fatal. The
usual causes of death of patients with motor neuron diseases are not
directly related to the disease, but result from simultaneous
additional illnesses which ultimately occur because of weakness of
the body. These illnesses are often infections. ALS usually leads to death within 5 years of the time the diagnosis of ALS is made; the range is from 2 to 7 years.
stimulation to the muscles. This stimulation is necessary for the movement of body parts.
Amyotrophic lateral sclerosis is quite a mouthful. The disease is therefore usually referred to simply as ALS or in North America as Lou Gehrig's disease after the great baseball player who died of it.
ALS strikes in mid-life, most often in the fifth through seventh decades of life. Men are about one-and-a-half
times more likely to have the disease as women.
ALS occurs when specific nerve cells in the brain and spinal
cord that control voluntary movement gradually degenerate. The loss
of these motor neurons causes the muscles under their control to
weaken and waste away, leading to paralysis.
ALS manifests itself in different ways, depending on which muscles weaken first. Symptoms may include
tripping and falling, loss of motor control in hands and arms,
difficulty speaking, swallowing and/or breathing, persistent fatigue,
and twitching and cramping, sometimes quite severely.
There is no cure for ALS; nor is there a proven therapy that will prevent or reverse the course of the disorder. The
Food and Drug Administration (FDA) approved riluzole, the first drug
that has been shown to prolong the survival of ALS patients. Patients
may also receive supportive treatments that address some symptoms.
ALS is progressive and fatal. The
usual causes of death of patients with motor neuron diseases are not
directly related to the disease, but result from simultaneous
additional illnesses which ultimately occur because of weakness of
the body. These illnesses are often infections. ALS usually leads to death within 5 years of the time the diagnosis of ALS is made; the range is from 2 to 7 years.
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